Description: Omarigliptin, also known as
MK-3102, is a potent and long-acting DPP-4 inhibitor for once-weekly treatment
of type 2 diabetes. MK-3102 (omarigliptin), was identified as a potent and
selective dipeptidyl peptidase 4 (DPP-4) inhibitor with an excellent
pharmacokinetic profile amenable for once-weekly human dosing and selected as a
clinical development candidate. Omarigliptin is currently in phase 3 clinical
development.
Synonym: MK3102; MK-3102; MK 3102;
Omarigliptin
IUPAC/Chemical Name: (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine
SMILES Code: N[C@@H]1[C@@H](C2=CC(F)=CC=C2F)OC[C@H](N3CC4=NN(S(=O)(C)=O)C=C4C3)C1
Name: Omarigliptin
CAS#: 1226781-44-7
Chemical Formula: C17H20F2N4O3S
Exact Mass: 398.12242
Molecular Weight: 398.43
Elemental Analysis: C, 51.25; H, 5.06; F, 9.54; N, 14.06; O, 12.05; S, 8.05We produce Omarigliptin, MK-3102, 1226781-44-7 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
Omarigliptin, MK-3102, 1226781-44-7 Intermediates, we have 8; Omarigliptin, MK-3102, 1226781-44-7 Impurity we have 10, all from GMP, FDA plant.
Now Omarigliptin, MK-3102, 1226781-44-7 DMF document is preparing.
Until 2016, Aug, Omarigliptin, MK-3102, 1226781-44-7 more than produced 25kg API, 120kg Intermediates
Name: Omarigliptin
CAS#: 1226781-44-7
Chemical Formula: C17H20F2N4O3S
Exact Mass: 398.12242
Molecular Weight: 398.43
Elemental Analysis: C, 51.25; H, 5.06; F, 9.54; N, 14.06; O, 12.05; S, 8.05We produce Omarigliptin, MK-3102, 1226781-44-7 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
Omarigliptin, MK-3102, 1226781-44-7 Intermediates, we have 8; Omarigliptin, MK-3102, 1226781-44-7 Impurity we have 10, all from GMP, FDA plant.
Now Omarigliptin, MK-3102, 1226781-44-7 DMF document is preparing.
Until 2016, Aug, Omarigliptin, MK-3102, 1226781-44-7 more than produced 25kg API, 120kg Intermediates
| Omarigliptin | MK-3102;Marizev | 1226781-44-7 |
| Omarigliptin Intermediates | (2S,3R,5S)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine | 1443380-88-8 |
| Omarigliptin Intermediates | Tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate | 1280210-79-8 |
| Omarigliptin Intermediates | 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 4-methylbenzenesulfonate | 18193664-02-7 |
| Omarigliptin Intermediates | Tert-butyl 2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate | 1226781-82-3 |
| Omarigliptin Intermediates | (Z)-tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate | 905274-02-4 |
| Omarigliptin Intermediates | Tert-butyl 6a-hydroxy-1,2,6,6a-tetrahydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate | 1211594-55-6 |
| Omarigliptin Intermediates | 2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole | 1226781-80-1 |
| Omarigliptin Intermediates | 2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole benzenesulfonate | 1280210-80-1 |
| Omarigliptin Intermediates | Tert-butyl ((2R,3R)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate | 1456616-43-5 |
| Omarigliptin Intermediates | Tert-butyl ((2S,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate | 1456616-44-6 |
| Omarigliptin Intermediates | (2R,3R,5R)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine | |
| Omarigliptin Intermediates | (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine | |
| Omarigliptin Intermediates | Tert-butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate | 1172623-99-2 |
| Omarigliptin Intermediates | 2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid | 61172-66-5 |
| Omarigliptin Intermediates | Tert-butyl (1-(methoxy(methyl)amino)-1-oxopent-4-yn-2-yl)carbamate | 172623-95-8 |
| Omarigliptin Intermediates | Tert-butyl (1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-yl)carbamate | 1172623-96-9 |
| Omarigliptin Intermediates | (2R,3S,5R)-2-(3-fluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine impurity A |
|
| Omarigliptin Intermediates | (2R,3S,5R)-2-(2-fluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine impurity B |
