GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8, we are China TOP supplier.
EOS Med Chem produce GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8, EOS Med Chem have 8; 1103738-19-7 Impurity we have 10, all from GMP, FDA plant.
Now GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8 DMF document is preparing.
Until 2016, Aug, GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8 more than produced 25kg API, 120kg Intermediates
2017 China CPHI: E1M35
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Description: Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
Name: Niraparib HCl
CAS#: 1038915-64-8 (HCl)
Chemical Formula: C19H21ClN4O
Exact Mass: 356.1404
Molecular Weight: 356.854
Elemental Analysis: C, 63.95; H, 5.93; Cl, 9.93; N, 15.70; O, 4.48
Related CAS #: 1038915-60-4 (free base) 1038915-64-8 (HCl) 1038915-73-9 (tosylate) 1613220-15-7 (tosylate hydrate)
Synonym: MK4827; MK 4827; MK4827; Niraparib; Niraparib HCl; Niraparib hydrochloride.
IUPAC/Chemical Name: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride
InChi Key: YXYDNYFWAFBCAN-PFEQFJNWSA-N
InChi Code: InChI=1S/C19H20N4O.ClH/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);1H/t14-;/m1./s1
SMILES Code: O=C(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C12)N.[H]Cl
Name: Niraparib HCl
CAS#: 1038915-64-8 (HCl)
Chemical Formula: C19H21ClN4O
Exact Mass: 356.1404
Molecular Weight: 356.854
Elemental Analysis: C, 63.95; H, 5.93; Cl, 9.93; N, 15.70; O, 4.48
Related CAS #: 1038915-60-4 (free base) 1038915-64-8 (HCl) 1038915-73-9 (tosylate) 1613220-15-7 (tosylate hydrate)
Synonym: MK4827; MK 4827; MK4827; Niraparib; Niraparib HCl; Niraparib hydrochloride.
IUPAC/Chemical Name: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride
InChi Key: YXYDNYFWAFBCAN-PFEQFJNWSA-N
InChi Code: InChI=1S/C19H20N4O.ClH/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);1H/t14-;/m1./s1
SMILES Code: O=C(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C12)N.[H]Cl
