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執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Description: KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.
Name: KM11060
CAS#: 774549-97-2
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:
Synonym: KM11060; KM-11060; KM 11060.
IUPAC/Chemical Name: 7-chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)quinoline
InChi Key: GIEHIZKCIZLXLF-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
SMILES Code: O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C23)CC1)(C4=CC=C(Cl)C=C4)=O
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
REFERENCES
1: Wu H, Yang J, Su EM, Li L, Zhao C, Yang X, Gao Z, Pan M, Sun P, Sun W, Jiang
Y, Su X. Lipoxin A4 and platelet activating factor are involved in E. coli or
LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar
26;9(3):e93003. doi: 10.1371/journal.pone.0093003. eCollection 2014. PubMed PMID:
24671173; PubMed Central PMCID: PMC3966846.
2: Loo TW, Bartlett MC, Shi L, Clarke DM. Corrector-mediated rescue of
misprocessed CFTR mutants can be reduced by the P-glycoprotein drug pump. Biochem
Pharmacol. 2012 Feb 1;83(3):345-54. doi: 10.1016/j.bcp.2011.11.014. Epub 2011 Nov
28. PubMed PMID: 22138447.
3: Robert R, Carlile GW, Pavel C, Liu N, Anjos SM, Liao J, Luo Y, Zhang D, Thomas
DY, Hanrahan JW. Structural analog of sildenafil identified as a novel corrector
of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89.
Epub 2007 Nov 1. PubMed PMID: 17975008.
