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2018年7月29日星期日

Biggest Manufacturer,Encorafenib  (1269440-17-6 ) and Intermediates.

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.



                                                           2018 Korea CPHI, C30




EOS Med Chem, Medchem is Big
執大象,天下往,往而無害,安平泰

WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.



1.
Encorafenib, CAS#1269440-17-6, HNMR, HPLC 99%+, LCMS, COA, MSDS and ROS, more than 1KG in stock, pls check:

Name: Encorafenib
CAS#: 1269440-17-6,
Formula: C22H27ClFN7O4S
Exact Mass: 539.15178 
Molecular Weight: 540.01 
Elemental Analysis: C, 48.93; H, 5.04; Cl, 6.57; F, 3.52; N, 18.16; O, 11.85; S, 5.94
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)


2.
Encorafenib Intermediates:

1.Tert-butyl 5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate, cas#1269440-69-8, we have more than 1kg in stock, assay 99% in GMP plant, CGMP standard, now COA, NMR, HPLC, MS is ok.


 2.(S)-methyl (1-aminopropan-2-yl)carbamate, cas#1229025-89-1, we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

3.methyl N-[(2S)-1-aminopropan-2-yl]carbamate,hydrochloride,
 cas#1229025-32-4, we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

4.2-chloro-4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidine,
 cas#1269440-58-5, we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.


5.(S)-methyl 1-(4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
 cas#1269440-60-9, we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.


6.Tert-butyl 3-bromo-5-chloro-2-fluorophenyl-carbamate,
 cas#1269232-94-1, we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.


References


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7: Pascual LL, Muruzàbal RS, Gigli ML, Bayona JI. Cutaneous toxicity of a new BRAF inhibitor, LGX818 (encorafenib). Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):102-104. doi: 10.4103/0378-6323.191130. PubMed PMID: 27679406.

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9: Asati V, Bharti SK, Mahapatra DK. Mutant B-Raf Kinase Inhibitors as Anticancer Agents. Anticancer Agents Med Chem. 2016;16(12):1558-1575. Review. PubMed PMID: 27264268.

10: Masuishi T, Muro K. [Current Progress and Feasibility of Using Molecular-Targeted Agent Combinations for Metastatic Colorectal Cancer]. Gan To Kagaku Ryoho. 2016 Apr;43(4):408-12. Japanese. PubMed PMID: 27220786.

11: Henning B, Stieger P, Kamarachev J, Dummer R, Goldinger SM. Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation. Melanoma Res. 2016 Jun;26(3):304-7. doi: 10.1097/CMR.0000000000000248. PubMed PMID: 27116335.

12: Adelmann CH, Ching G, Du L, Saporito RC, Bansal V, Pence LJ, Liang R, Lee W, Tsai KY. Comparative profiles of BRAF inhibitors: the paradox index as a predictor of clinical toxicity. Oncotarget. 2016 May 24;7(21):30453-60. doi: 10.18632/oncotarget.8351. PubMed PMID: 27028853; PubMed Central PMCID: PMC5058692.

13: Krepler C, Xiao M, Sproesser K, Brafford PA, Shannan B, Beqiri M, Liu Q, Xu W, Garman B, Nathanson KL, Xu X, Karakousis GC, Mills GB, Lu Y, Ahmed TA, Poulikakos PI, Caponigro G, Boehm M, Peters M, Schuchter LM, Weeraratna AT, Herlyn M. Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies. Clin Cancer Res. 2016 Apr 1;22(7):1592-602. doi: 10.1158/1078-0432.CCR-15-1762. Epub 2015 Dec 16. PubMed PMID: 26673799; PubMed Central PMCID: PMC4818716.

14: Li Z, Jiang K, Zhu X, Lin G, Song F, Zhao Y, Piao Y, Liu J, Cheng W, Bi X, Gong P, Song Z, Meng S. Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2016 Jan 28;370(2):332-44. doi: 10.1016/j.canlet.2015.11.015. Epub 2015 Nov 14. PubMed PMID: 26586345.

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17: Scartozzi M, Giampieri R, Aprile G, Iacono D, Santini D, dell'Aquila E, Silvestris N, Gnoni A, Bonotto M, Puzzoni M, Demurtas L, Cascinu S. The distinctive molecular, pathological and clinical characteristics of BRAF-mutant colorectal tumors. Expert Rev Mol Diagn. 2015;15(8):979-87. doi: 10.1586/14737159.2015.1047346. Epub 2015 May 15. Review. PubMed PMID: 25975986.

18: Trinh VA, You Y, Hwu WJ. Treatment of BRAF-mutated advanced cutaneous melanoma. Chin Clin Oncol. 2014 Sep;3(3):28. doi: 10.3978/j.issn.2304-3865.2014.05.10. PubMed PMID: 25841454.

19: Galliker NA, Murer C, Kamarashev J, Dummer R, Goldinger SM. Clinical observation of panniculitis in two patients with BRAF-mutated metastatic melanoma treated with a combination of a BRAF inhibitor and a MEK inhibitor. Eur J Dermatol. 2015 Apr;25(2):177-80. doi: 10.1684/ejd.2014.2512. PubMed PMID: 25788221.

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