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2018年7月30日星期一

Biggest Manufacturer, Palbociclib (571190-30-2) and Intermediates.

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.


2018 Korea CPHI, C30 


EOS Med Chem, Medchem is Big
執大象,天下往,往而無害,安平泰

WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.





1.
Palbociclib, CAS#571190-30-2, HNMR, HPLC 99%+, LCMS, COA, MSDS and ROS, more than 1KG in stock, pls check:
Name: Palbociclib
CAS#: 571190-30-2
Formula:C24H29N7O2 
Exact Mass: 447.23827 
Molecular Weight: 447.543 
Elemental Analysis: C, 64.41; H, 6.53; N, 21.91; O, 7.15
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)

2. 
Palbociclib Intermediates:

1. Ponatinib Intermediate:4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
cas#571188-59-5
we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
2.Ponatinib Intermediate:2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
cas#1013916-37-4
we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
3.Ponatinib Intermediate:6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
cas#1016636-76-2
we have more than 1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

References

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10: Lu J. Palbociclib: a first-in-class CDK4/CDK6 inhibitor for the treatment of hormone-receptor positive advanced breast cancer. J Hematol Oncol. 2015 Aug 13;8:98. doi: 10.1186/s13045-015-0194-5. PubMed PMID: 26264704; PubMed Central PMCID: PMC4534142.
11: Palbociclib (Ibrance) for metastatic breast cancer. Med Lett Drugs Ther. 2015 Aug 17;57(1475):115-6. PubMed PMID: 26262882.
12: McCain J. First-in-Class CDK4/6 Inhibitor Palbociclib Could Usher in a New Wave of Combination Therapies for HR+, HER2- Breast Cancer. P T. 2015 Aug;40(8):511-20. PubMed PMID: 26236140; PubMed Central PMCID: PMC4517534.
13: Carey LA, Perou CM. Palbociclib--Taking Breast-Cancer Cells Out of Gear. N Engl J Med. 2015 Jul 16;373(3):273-4. doi: 10.1056/NEJMe1506680. PubMed PMID: 26176385.
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