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EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.
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EOS Med Chem, Medchem is Big
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1.
Obeticholic acid, CAS#459789-99-2, HNMR, HPLC 99%+, LCMS, COA, MSDS and ROS, more than 1KG in stock, pls check:
Name:Obeticholic acid
CAS#: 459789-99-2
Formula: C26H44O4
Exact Mass: 420.32396
Molecular Weight: 420.63
Elemental Analysis: C, 74.24; H, 10.54; O, 15.21
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
2.
Obeticholic Intermediates:
1. 3α-Hydroxy-7-Oxo-5β-Cholanic Acid
cas#4651-67-6
we have more than 14kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
2.3α-hydroxy-6-ethylidene-7-oxo-5β-cholanoic acid
cas#1516887-33-4
we have more than 23kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
3.3α-hydroxy-6α-ethyl-7-oxo-5β-cholanoic acid
Cas#915038-26-5
We have more than 19kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
4.7-ketolithocholic Methyl ester
Cas#10538-59-7
We have more than 21kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
5. (EZ)-3-hydroxy-6-ethylidene-7-keto-5-cholan-24-oic acid methyl ester
Cas#863239-59-2
We have more than 19kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
6.Obeticholic acid Intermediate
Cas#1953137-50-2
We have more than 17kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
7.Obeticholic acid Intermediate
Cas# 1227612-51-2
We have more than 14kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
8.Obeticholic acid Intermediate
Cas#2124210-49-5
We have more than 23kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
References
1: Armstrong MJ, Newsome PN. Trials of obeticholic acid for non-alcoholic steatohepatitis. Lancet. 2015 Jul 4;386(9988):28. doi: 10.1016/S0140-6736(15)61199-0. PubMed PMID: 26169862.
2: Neuschwander-Tetri BA, Van Natta ML, Tonascia J, Brunt EM, Kleiner DE. Trials of obeticholic acid for non-alcoholic steatohepatitis - Authors' reply. Lancet. 2015 Jul 4;386(9988):28-9. doi: 10.1016/S0140-6736(15)61200-4. PubMed PMID: 26169861.
3: Musso G, Cassader M, Gambino R. Trials of obeticholic acid for non-alcoholic steatohepatitis. Lancet. 2015 Jul 4;386(9988):27. doi: 10.1016/S0140-6736(15)61198-9. PubMed PMID: 26169860.
4: Dong R, Zheng S, Chen G. The Appropriate Timing and Dose of Obeticholic Acid in Patients With Primary Biliary Cirrhosis. Gastroenterology. 2015 Aug;149(2):508. doi: 10.1053/j.gastro.2015.01.050. Epub 2015 Jun 29. PubMed PMID: 26136168.
5: Arrese M, Cabrera D, Barrera F. Obeticholic acid: expanding the therapeutic landscape of NASH. Ann Hepatol. 2015 May-Jun;14(3):430-2. PubMed PMID: 25864227.
6: Musso G. Obeticholic acid and resveratrol in nonalcoholic fatty liver disease: all that is gold does not glitter, not all those who wander are lost. Hepatology. 2015 Jun;61(6):2104-6. doi: 10.1002/hep.27772. Epub 2015 Apr 8. PubMed PMID: 25753820.
7: Wong VW, Wong GL, Chan FK. Is obeticholic Acid the solution to nonalcoholic steatohepatitis? Gastroenterology. 2015 Apr;148(4):851-2. doi: 10.1053/j.gastro.2015.02.044. Epub 2015 Feb 26. PubMed PMID: 25726736.
8: Verbeke L, Farre R, Verbinnen B, Covens K, Vanuytsel T, Verhaegen J, Komuta M, Roskams T, Chatterjee S, Annaert P, Vander Elst I, Windmolders P, Trebicka J, Nevens F, Laleman W. The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats. Am J Pathol. 2015 Feb;185(2):409-19. doi: 10.1016/j.ajpath.2014.10.009. Epub 2015 Jan 12. PubMed PMID: 25592258.
9: Hirschfield GM, Mason A, Luketic V, Lindor K, Gordon SC, Mayo M, Kowdley KV, Vincent C, Bodhenheimer HC Jr, Parés A, Trauner M, Marschall HU, Adorini L, Sciacca C, Beecher-Jones T, Castelloe E, Böhm O, Shapiro D. Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology. 2015 Apr;148(4):751-61.e8. doi: 10.1053/j.gastro.2014.12.005. Epub 2014 Dec 11. PubMed PMID: 25500425.
10: Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, Chalasani N, Dasarathy S, Diehl AM, Hameed B, Kowdley KV, McCullough A, Terrault N, Clark JM, Tonascia J, Brunt EM, Kleiner DE, Doo E; NASH Clinical Research Network. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 2015 Mar 14;385(9972):956-65. doi: 10.1016/S0140-6736(14)61933-4. Epub 2014 Nov 7. Erratum in: Lancet. 2015 Mar 14;385(9972):946. PubMed PMID: 25468160; PubMed Central PMCID: PMC4447192.
