Efinaconazole
API Name: Efinaconazole
CAS#: 164650-44-6
Formula: C18H22F2N4O
Exact Mass: 348.1762
Molecular Weight: 348.39
Elemental Analysis: C, 62.05; H, 6.36; F, 10.91; N, 16.08; O, 4.59
We have more than2.5kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
Efinaconazole intermediates
1.Name:(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol
CAS:133775-25-4
Structural formula:
We have more than1.8kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
2.Name:QANJLSHZDUOBBP-QPUJVOFHSA-N
CAS:127000-90-2
Structural formula:
We have more than2.3kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
3.Name:4-methylenepiperidine hydrochloride; 4-methylidenepiperidine hydrochloride
CAS:144230-50-2
Structural formula:
We have more than1.7kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
Contact information：
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Efinaconazole impurities
Efinaconazole Impurity 1
Efinaconazole Impurity 2
Efinaconazole Impurity 3
Efinaconazole Impurity 4
Efinaconazole Impurity 5
Efinaconazole Impurity 6
Reference
1: Pollak RA. Efinaconazole topical solution, 10% the development of a new topical treatment for toenail onychomycosis. J Am Podiatr Med Assoc. 2014 Nov;104(6):568-73. doi: 10.7547/8750-7315-104.6.568. PubMed PMID: 25514267.
2: Tosti A, Elewski BE. Treatment of onychomycosis with efinaconazole 10% topical solution and quality of life. J Clin Aesthet Dermatol. 2014 Nov;7(11):25-30. PubMed PMID: 25489379; PubMed Central PMCID: PMC4255695.
3: Gupta AK, Simpson FC, Abramovits W, Scheinfeld N. Efinaconazole 10% nail solution: a post-FDA approval update. Skinmed. 2014 Jul-Aug;12(4):235-7. PubMed PMID: 25335353.
4: Zeichner JA, Stein Gold L, Korotzer A. Penetration of ((14)C)-Efinaconazole Topical Solution, 10%, Does Not Appear to be Influenced by Nail Polish. J Clin Aesthet Dermatol. 2014 Sep;7(9):34-6. PubMed PMID: 25276275; PubMed Central PMCID: PMC4174918.
5: Joseph WS, Vlahovic TC, Pillai R, Olin JT. Efinaconazole 10% solution in the treatment of onychomycosis of the toenails. J Am Podiatr Med Assoc. 2014 Sep-Oct;104(5):479-85. doi: 10.7547/0003-0538-104.5.479. PubMed PMID: 25275736.
6: Efinaconazole topical solution (Jublia) for onychomycosis. Med Lett Drugs Ther. 2014 Sep 15;56(1451):88-9. PubMed PMID: 25211303.
7: Jo W, Glynn M, Nejishima H, Sanada H, Minowa K, Calvarese B, Senda H, Pillai R, Mutter L. Nonclinical safety assessment of Efinaconazole Solution (10%) for onychomycosis treatment. Regul Toxicol Pharmacol. 2014 Oct;70(1):242-53. doi: 10.1016/j.yrtph.2014.07.012. Epub 2014 Jul 16. PubMed PMID: 25038564.
8: Gupta AK, Elewski BE, Sugarman JL, Ieda C, Kawabata H, Kang R, Pillai R, Olin JT, Watanabe S. The efficacy and safety of efinaconazole 10% solution for treatment of mild to moderate onychomycosis: a pooled analysis of two phase 3 randomized trials. J Drugs Dermatol. 2014 Jul;13(7):815-20. PubMed PMID: 25007364.
9: Iwata A, Watanabe Y, Kumagai N, Katafuchi-Nagashima M, Sugiura K, Pillai R, Tatsumi Y. In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal. Antimicrob Agents Chemother. 2014 Aug;58(8):4920-2. doi: 10.1128/AAC.02703-13. Epub 2014 May 27. PubMed PMID: 24867968; PubMed Central PMCID: PMC4136074.
10: Gupta AK, Simpson FC. Efinaconazole (Jublia) for the treatment of onychomycosis. Expert Rev Anti Infect Ther. 2014 Jul;12(7):743-52. doi: 10.1586/14787210.2014.919852. Epub 2014 May 22. PubMed PMID: 24850511.
