Follow EOS to learn more about Acalabrutinib 241479-67-4
API: Isavuconazonium sulfate
CAS:946075-13-4
Chemical Formula: C35H36F2N8O9S2
Molecular Weight: 814.84
Elemental Analysis: C, 51.59; H, 4.45; F, 4.66; N, 13.75; O, 17.67; S, 7.87
Molecular Weight: 814.84
Elemental Analysis: C, 51.59; H, 4.45; F, 4.66; N, 13.75; O, 17.67; S, 7.87
Structural formula:
Part one : Isavuconazole( 241479-67-4 )and Intermediates
Product name:Isavuconazole
CAS:241479-67-4
Chemical Formula: C22H17F2N5OS
Exact Mass: 437.1122
Molecular Weight: 437.4688
Elemental Analysis: C, 60.40; H, 3.92; F, 8.69; N, 16.01; O, 3.66; S, 7.33
Exact Mass: 437.1122
Molecular Weight: 437.4688
Elemental Analysis: C, 60.40; H, 3.92; F, 8.69; N, 16.01; O, 3.66; S, 7.33
Structural formula:
We have more than1kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
➤ Acalabrutinib Intermeidtaes:
1.Name:(2R,3R)-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol
cas:241479-72-1
Structural formula:
We have more than2.5kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
2.Name:QYOWWJNQQPRWCO-QPUJVOFHSA-N
CAS:241479-73-2
Structural formula:
We have more than1.5kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
3.Name:SYSUFNUKZJVPBI-TVQRCGJNSA-N
CAS:241479-74-3
Structural formula:
We have more than1.2kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
4.Name: (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)
butanethioamide cas:368421-58-3
Structural formula:
We have more than2.3kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
5.Name: [2-(methylamino)pyridin-3-yl]methanol
CAS:32399-12-5
Structural formula:
We have more than2.6kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
6.Name:(2-(Methylamino)pyridin-3-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
CAS:1180002-01-0
Structural formula:
We have more than1.7kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
7.Name:(2-(((1-Chloroethoxy)carbonyl)(methyl)amino)pyridin-3-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
CAS:338990-31-1
Structural formula:
We have more than1.9kg in stock, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.
Contact information：
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
Part two: Isavuconazole impurities
➤➤Isavuconazole impurities :
Isavuconazole Impurity1
Isavuconazole Impurity2
Isavuconazole Impurity3
Isavuconazole Impurity4
Isavuconazole Impurity5
Isavuconazole Impurity6
Isavuconazole Impurity7
Isavuconazole Impurity8
Isavuconazole Impurity9
Isavuconazole Impurity10
Isavuconazole Impurity11
Isavuconazole Impurity12
Isavuconazole Impurity13
Isavuconazole Impurity14
Isavuconazole Impurity15
Isavuconazole Impurity16
Isavuconazole Impurity17
Isavuconazole Impurity18
Isavuconazole Impurity19
Isavuconazole Impurity20
Isavuconazole Impurity21
Isavuconazole Impurity22
Isavuconazole Impurity23
Isavuconazole Impurity24
Isavuconazole Impurity25
Isavuconazole Impurity26
Isavuconazole Impurity27
Isavuconazole Impurity28
Isavuconazole Impurity29
Isavuconazole Impurity30
Contact information：
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.
➤➤➤Reference
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2: Wiederhold NP, Kovanda L, Najvar LK, Bocanegra R, Olivo M, Kirkpatrick WR, Patterson TF. Isavuconazole is Effective for the Treatment of Experimental Cryptococcal Meningitis. Antimicrob Agents Chemother. 2016 Jun 20. pii: AAC.00229-16. [Epub ahead of print] PubMed PMID: 27324761.
3: Desai A, Yamazaki T, Dietz AJ, Kowalski D, Lademacher C, Pearlman H, Akhtar S, Townsend R. Pharmacokinetic and Pharmacodynamic Evaluation of the Drug-Drug Interaction between Isavuconazole and Warfarin in Healthy Subjects. Clin Pharmacol Drug Dev. 2016 Jun 9. doi: 10.1002/cpdd.283. [Epub ahead of print] PubMed PMID: 27278712.
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5: Groll AH, Desai A, Han D, Howieson C, Kato K, Akhtar S, Kowalski D, Lademacher C, Lewis W, Pearlman H, Mandarino D, Yamazaki T, Townsend R. Pharmacokinetic Assessment of Drug-Drug Interactions of Isavuconazole with the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults. Clin Pharmacol Drug Dev. 2016 Jun 8. doi: 10.1002/cpdd.284. [Epub ahead of print] PubMed PMID: 27273343.
6: Yamazaki T, Desai A, Han D, Kato K, Kowalski D, Akhtar S, Lademacher C, Kovanda L, Townsend R. Pharmacokinetic Interaction between Isavuconazole and a Fixed-Dose Combination of Lopinavir 400 mg/Ritonavir 100 mg in Healthy Subjects. Clin Pharmacol Drug Dev. 2016 Jun 8. doi: 10.1002/cpdd.282. [Epub ahead of print] PubMed PMID: 27273248.
7: Yamazaki T, Desai A, Goldwater R, Han D, Howieson C, Akhtar S, Kowalski D, Lademacher C, Pearlman H, Rammelsberg D, Townsend R. Pharmacokinetic Effects of Isavuconazole Co-Administration with the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects. Clin Pharmacol Drug Dev. 2016 Jun 8. doi: 10.1002/cpdd.281. [Epub ahead of print] PubMed PMID: 27273149.
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9: Kovanda LL, Desai AV, Lu Q, Townsend RW, Akhtar S, Bonate P, Hope WW. Isavuconazole Population Pharmacokinetic Analysis Using Non-Parametric Estimation in Patients with Invasive Fungal Disease: Results from the VITAL Study. Antimicrob Agents Chemother. 2016 May 16. pii: AAC.00514-16. [Epub ahead of print] PubMed PMID: 27185799.
10: Thompson GR 3rd, Rendon A, Ribeiro Dos Santos R, Queiroz-Telles F, Ostrosky-Zeichner L, Azie N, Maher R, Lee M, Kovanda L, Engelhardt M, Vazquez JA, Cornely OA, Perfect JR. Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses. Clin Infect Dis. 2016 May 11. pii: ciw305. [Epub ahead of print] PubMed PMID: 27169478.
11: Graves B, Morrissey CO, Wei A, Coutsouvelis J, Ellis S, Pham A, Gooi J, Ananda-Rajah M. Isavuconazole as salvage therapy for mucormycosis. Med Mycol Case Rep. 2016 Mar 8;11:36-9. doi: 10.1016/j.mmcr.2016.03.002. eCollection 2016 Mar. PubMed PMID: 27158585; PubMed Central PMCID: PMC4845387.
12: Kovanda LL, Petraitiene R, Petraitis V, Walsh TJ, Desai A, Bonate P, Hope WW. Pharmacodynamics of isavuconazole in experimental invasive pulmonary aspergillosis: implications for clinical breakpoints. J Antimicrob Chemother. 2016 Jul;71(7):1885-91. doi: 10.1093/jac/dkw098. Epub 2016 Apr 15. PubMed PMID: 27084921; PubMed Central PMCID: PMC4896411.
13: Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR 3rd, Alangaden GJ, Brown JM, Fredricks DN, Heinz WJ, Herbrecht R, Klimko N, Klyasova G, Maertens JA, Melinkeri SR, Oren I, Pappas PG, Ráčil Z, Rahav G, Santos R, Schwartz S, Vehreschild JJ, Young JH, Chetchotisakd P, Jaruratanasirikul S, Kanj SS, Engelhardt M, Kaufhold A, Ito M, Lee M, Sasse C, Maher RM, Zeiher B, Vehreschild MJ; VITAL and FungiScope Mucormycosis Investigators. Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis. Lancet Infect Dis. 2016 Mar 8. pii: S1473-3099(16)00071-2. doi: 10.1016/S1473-3099(16)00071-2. [Epub ahead of print] PubMed PMID: 26969258.
14: Roilides E, Antachopoulos C. Isavuconazole: an azole active against mucormycosis. Lancet Infect Dis. 2016 Mar 8. pii: S1473-3099(16)00127-4. doi: 10.1016/S1473-3099(16)00127-4. [Epub ahead of print] PubMed PMID: 26969257.
15: Horn D, Goff D, Khandelwal N, Spalding J, Azie N, Shi F, Franks B, Shorr AF. Hospital resource use of patients receiving isavuconazole vs voriconazole for invasive mold infections in the phase III SECURE trial. J Med Econ. 2016 Jul;19(7):728-34. doi: 10.3111/13696998.2016.1164175. Epub 2016 Mar 30. PubMed PMID: 26960060.
16: Ahmed Y, Delaney S, Markarian A. Successful Isavuconazole therapy in a patient with acute invasive fungal rhinosinusitis and acquired immune deficiency syndrome. Am J Otolaryngol. 2016 Mar-Apr;37(2):152-5. doi: 10.1016/j.amjoto.2015.12.003. Epub 2015 Dec 9. PubMed PMID: 26954873.
17: Desai A, Schmitt-Hoffmann AH, Mujais S, Townsend R. Population Pharmacokinetics of Isavuconazole in Subjects with Mild or Moderate Hepatic Impairment. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3025-31. doi: 10.1128/AAC.02942-15. Print 2016 May. PubMed PMID: 26953193; PubMed Central PMCID: PMC4862513.
18: Petraitis V, Petraitiene R, Moradi PW, Strauss GE, Katragkou A, Kovanda LL, Hope WW, Walsh TJ. Pharmacokinetics and Concentration-Dependent Efficacy of Isavuconazole for Treatment of Experimental Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2718-26. doi: 10.1128/AAC.02665-15. Print 2016 May. PubMed PMID: 26883703; PubMed Central PMCID: PMC4862472.
19: Arendrup MC, Meletiadis J, Mouton JW, Guinea J, Cuenca-Estrella M, Lagrou K, Howard SJ; Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST). EUCAST technical note on isavuconazole breakpoints for Aspergillus, itraconazole breakpoints for Candida and updates for the antifungal susceptibility testing method documents. Clin Microbiol Infect. 2016 Feb 3. pii: S1198-743X(16)00077-X. doi: 10.1016/j.cmi.2016.01.017. [Epub ahead of print] PubMed PMID: 26851656.
20: Slavin MA, Thursky KA. Isavuconazole: a role for the newest broad-spectrum triazole. Lancet. 2016 Feb 20;387(10020):726-8. doi: 10.1016/S0140-6736(15)01218-0. Epub 2015 Dec 10. PubMed PMID: 26684608.
