Introduction to Voxtalisib

Voxtalisib, FDA approved new drug will be a big potential drug.

Original Route of Synthesis of  Voxtalisib yield is about 12.3%, impurity is 2%, unknown impurity is 1%.

EOS Med Chem use the new Route of Synthesis of Voxtalisib, yield improve 24.4%.

Reduced Voxtalisib synthesis steps, Remove unknown impurity, Remove Toxic Chemicals， Impurity is less than 1%, Assay more than 99%, Water by KF less than 0.5%.

Below is EOS Med Chem Route of Synthesis of Voxtalisib, each steps we have MSDS, COA, if you have interesting, pls contact me.

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Voxtalisib Intermediate: (1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)boronic acid(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)boronic acid1105511-68-91105511-68-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.8kg

Voxtalisib Intermediate: 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole449758-17-2449758-17-2, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 5.6kg

Voxtalisib Intermediate: 4-chloro-6-methyl-2-(methylthio)pyrimidine4-chloro-6-methyl-2-(methylthio)pyrimidine17119-73-217119-73-2, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.9kg

Voxtalisib Intermediate: 6-methyl-2-(methylthio)pyrimidin-4(3H)-one6-methyl-2-(methylthio)pyrimidin-4(3H)-one6328-58-16328-58-1, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8kg

Voxtalisib Intermediate: 8-ethyl-4-methyl-2-(methylthio)-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one8-ethyl-4-methyl-2-(methylthio)-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one934493-81-9934493-81-9, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 8.6kg

Voxtalisib Intermediate: 8-ethyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one8-ethyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one934493-79-5934493-79-5, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 4.4kg

Voxtalisib Intermediate: N-ethyl-5-iodo-6-methyl-2-(methylthio)pyrimidin-4-amineN-ethyl-5-iodo-6-methyl-2-(methylthio)pyrimidin-4-amine934493-77-3934493-77-3, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 7.2kg

Voxtalisib Intermediate: N-ethyl-6-methyl-2-(methylthio)pyrimidin-4-amineN-ethyl-6-methyl-2-(methylthio)pyrimidin-4-amine537040-78-1537040-78-1, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 1.9kg

Voxtalisib Intermediate: XL765;SAR245409XL765;SAR245409934493-76-2934493-76-2, White powder, HPLC more than 98%, COA, MSDS, ROS is ok. Stock 2.9kg

COA-Voxtalisib

MSDS-Voxtalisib