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2016年2月19日星期五

Grazoprevir (MK5172) ROS, Intermediates List /EOS Med Chem, Medicinal Chemical is Big

EOS Med Chem, now have 2 GMP plant in Taizhou city and ChongQing City. Regular produce some API and Intermediates and custom synthesis.

The plant have approved by CGMP, FDA, ISO. Customers TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others all audited.

Now my plant have 80 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

 Each day, we have new chemicals or price from my lab or plant.
Grazoprevir (MK5172)  1206524-85-7, now have 500g in stock. Assay more than 99%. HPLC, NMR, MS is ok.

 Attaching ROS of Grazoprevir (MK5172), pls kindly check below.


 As the fist Manu of Grazoprevir (MK5172)  1206524-85-7 , now each step of Intermediates we could produce by myself, regular production.

 And we are working on the impurity of this project.

 Now Intermediates list:
Grazoprevir Intermediates1206524-84-6
Grazoprevir Intermediates1206524-85-7   
Grazoprevir Intermediates1350619-77-0
Grazoprevir Intermediates1361028-94-5
Grazoprevir Intermediates1350514-68-9
Grazoprevir Intermediates1425038-19-2
Those are most need, if your need not, pls ask me.




2016 Shanghai CPHI, W5C47, Welcome!

EOS Med Chem, Medchem is Big

執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian





Synonyms(1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
copyRight
Molecular StructureCAS # 1206524-85-7, MK-5172, (1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid
Molecular FormulaC29H38N4O7
Molecular Weight554.63
CAS Registry Number1206524-85-7


Name(1R,2R)-2-(4-Pentyn-1-yl)cyclopropanol
copyRight
Molecular StructureCAS # 1350619-77-0, (1R,2R)-2-(4-Pentyn-1-yl)cyclopropanol
Molecular FormulaC8H12O
Molecular Weight124.18
CAS Registry Number1350619-77-0
Properties
SolubilitySoluble (15 g/L) (25 ºC), Calc.*
Density1.025±0.06 g/cm3 (20 ºC 760 Torr), Calc.*
Boiling point186.3±13.0 ºC (760 Torr), Calc.*
Flash point75.8±12.8 ºC, Calc.*
Synonyms(1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide cyclic (1→2)-ether; ; MK 5172
copyRight
Molecular StructureCAS # 1350514-68-9, Grazoprevir, (1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide cyclic (1→2)-ether, , MK 5172
Molecular FormulaC38H50N6O9S
Molecular Weight766.90
CAS Registry Number1350514-68-9
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sutezolid intermediate: CAS No.: 168828-73-7 (R)-(3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate.



sutezolid CAS Number 168828-58-8   intermediates: CAS No.: 168828-73-7   (R)-(3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate.

 Sutezolid (PNU-100480, PF-02341272) is an oxazolidinone antibiotic currently in development as a treatment for extensively drug-resistant tuberculosis.

 This is custom synthesis for Teva pharma.

 Use 3 months, we finish this project.

 Thanks.




2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年2月18日星期四

cabozantinib (S)-malate-CAS 1140909-48-3 /XRD, NMR, HPLC, MS/EOS Med Chem, Medicinal Chemical is Big



cabozantinib (S)-malate-CAS 1140909-48-3

 Supply to China Qilu Pharma, WuxiAPP to USA market.

 Assay more than 99.5%

 MAX impurity less than 0.05%

 Price, USD 11800/KG,10KG IN STOCK.

 Each batch about 30-50kg.

 Attaching NMR.

 Glad to ask me or visit CPHI.

 Now in China only we have N-1 and N-2 , 2 form for this API Attaching XRD for you.

 Oncology is my strong project.
2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱：gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016年2月17日星期三

5,7-Dihydroxy-2,2-Dimethyl-2,3-Dihydro-4H-Chromen-4-One 883-09-0

2016 Jan we accept Swiss company order, custom synthesis 5,7-Dihydroxy-2,2-Dimethyl-2,3-Dihydro-4H-Chromen-4-One   883-09-0.

Use 25 days, we finish this project.

Assay more than 98%.

Glad to ask us your interesting products.

Gu

2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian


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2016 Jan New batch Grazoprevir (MK5172) 1206524-85-7 ,assay more than 99%

2016 Jan New batch Grazoprevir (MK5172)  1206524-85-7 ,assay more than 99%

Jan 16th, 2016 we finished new batch 1kg.

Assay more than 99%. Loss on Drying less than 0.5%.

Good grade in GMP company.

Attaching COA for you.

Thanks.


2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435

Skype: willgutian
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2016年2月16日星期二

Sole GMP supplier of Grazoprevir (MK5172) 1350514-68-9, COA as attachment

Grazoprevir (MK5172) Intermediates, 1206524-85-7, MK-5172

Grazoprevir, also known as MK5172, is a drug approved for the treatment of hepatitis C. It was developed by Merck and completed Phase III trials, following promising results in Phase II when used in combination with the NS5A replication complex inhibitor elbasvir, either with or without ribavirin.Grazoprevir is a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets. It has good activity against a range of HCV genotype variants, including some that are resistant to most currently used antiviral medications. 

Synonym: MK-5172; MK 5172; MK5172; Grazoprevir. trade name: Zepatier‎.
Appearance:
Solid powder
Purity:
>99% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:
Soluble in DMSO, not in water
Shelf Life:
>5 years if stored properly
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
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Korea Dong-A pharma approved my 1378391-86-6, (2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

1378391-86-6, (2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester. This is new chemicals will be used in drug discovery. Below pic is my boss Gu Tian in Dong-A pharma.

This is a new project for Korea and Japan market. Now we could produce it assay more than 99% and impurity is better.

We use 3 moth slove all problems. Now each batch could be 10kg.
Below is HPLC
Name (2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
copyRight
Molecular Structure CAS # 1378391-86-6, (2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
 
Molecular Formula C14H22IN3O3
Molecular Weight 407.25
CAS Registry Number 1378391-86-6
   
Properties
 
Solubility Slightly Soluble (2.8 g/L) (25 ºC), Calc.*
Density 1.515±0.06 g/cm3 (20 ºC 760 Torr), Calc.*
   
*Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2015 ACD/Labs)
  
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2016年1月4日星期一

New ROS Lumacaftor | VX-809 | CAS#936727-05-8

EOS Med Chem, now have a GMP plant in Taizhou city. Regular produce some Intermediates and custom synthesis.

The plant have approved by TEVA, HIKMA, CIPLA, GLENMARK, MAYLAN and some others.

Now my plant have 40 workers, 15 Tech person, 4 high Tech person.

And my source team have 4 source man, each one have more than 10 years in China market, they are clear COST and DELIVERY time.

Each day, we have new chemicals or price from my lab or plant.

New ROS Lumacaftor | VX-809 | CAS#936727-05-8

Lumacaftor | VX-809 | CAS#936727-05-8, now API we have 1000g in stock.

 Intermediates, we could supply: 
89446-17-1, this is my sole route, use this Intermediates, only 2 step could finish the API. Assay more than 99%, Loss on drying, less than 0.5%.
220210-56-0, this is step raw material.  Assay more than 99%, Loss on drying, less than 0.5%.
862574-88-7, we have big advantage of this chemical, 12kg in stock.  Assay more than 99%, Loss on drying, less than 0.5%.
1378388-16-9, This is new step of chemical.
HPLC, NMR, MS, pls kindly check below.

 Welcome to ask me.


2016 Shanghai CPHI, W5C47, Welcome!
EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
網址: www.eosmedchem.com 
郵箱: gutian@eosmedchem.com; eosmedchem@gmail.com 
辦公室: 0086-531-69905422-806(直通)
攜帶番號 & WhatsApp: +8618653174435
Skype: willgutian
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2016 New Oncology List

2016 New Oncology List


API
1AZD37591626387-80-1＞99.5%
2Rucaparib283173-50-2＞99%
3AG-014699459868-92-9＞99%
4ABT-1991257044-40-8＞99%
5WZ40021213269-23-8＞99%
6WZ80401214265-57-2＞99%
7WZ31461214265-56-1＞99%
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GMP-AP26113 (CAS 1197958-12-5)

GMP-AP26113 (CAS 1197958-12-5)



AP26113
Int 1 (2-Aminophenyl)dimethylphosphine oxide1197953-47-1＞98%
Int 22,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine1197953-49-3＞98%
Int 31-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine1089279-91-3＞98%
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GMP• Ribociclib (CAS 1211441-98-3)

GMP• Ribociclib (CAS 1211441-98-3)

ribociclibAn orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation.

Ribociclib
（LEE011）
Int 17H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl-1211443-61-6＞98%
Int 2 tert-Butyl 4-(6-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylate1374639-78-7＞98%
Med-chemicals, I am big
Office line: 0086-531-69905422
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GMP-Abemaciclib (LY2835219) CAS 1231929-97-7

GMP-Abemaciclib (LY2835219) CAS 1231929-97-7

abemaciclibAn orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1.
Abemaciclib
(LY2835219)
N-(4-bromo-2,6-difluoro-phenyl)-N’-isopropyl-acetamidine1231930-29-2＞98%
Int 11H-BenziMidazole,6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)1231930-42-9＞98%
Int 2 5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-amine1180132-17-5＞98%
Int 34-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole1231930-37-2＞98%
Int 4 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole1231930-33-8＞98%
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GMP – Rociletinib (CO-1686) 1374640-70-6

GMP – Rociletinib (CO-1686) 1374640-70-6

Rociletinib (CO-1686) is a novel, oral, targeted covalent (irreversible) inhibitor of the cancer-causing mutant forms of epidermal growth factor receptor (EGFR) currently being studied for the treatment of non-small cell lung cancer (NSCLC). Rociletinib was designed to selectively target both the initial activating EGFR mutations and the dominant acquired T790M resistance mutation, while sparing wild-type, or normal EGFR at anticipated therapeutic doses, with an improved toxicity profile.
Rociletinib
(CO-1686)
 Rociletinib HydrobromideN/A＞98%
Int 1N-[3-[[2-Chloro-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]carbamic acid 1,1-dimethylethyl ester1374507-23-9＞98%
Int 2(3-Aminophenyl)carbamic acid tert-butyl ester68621-88-5＞98%
Int 34-(4-Acetyl-1-piperazinyl)-2-(methyloxy)aniline1021426-42-5＞98%
Int 41-Acetyl-4-[3-(methyloxy)-4-nitrophenyl]piperazine1116229-11-8＞98%

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New Oncology: HM-61713 CAS 1802181-20-9 (BI-1482694) Intermediates all from GMP plant is coming

New Oncology: HM-61713 CAS 1802181-20-9 (BI-1482694) Intermediates all from GMP plant is coming

Boehringer Ingelheim
As 2016, EOS Med new project, now each batch is about 10kg, we have 3kg in stock. Welcome to ask.
Int 1N/AN/A＞98%
Int 2N/AN/A＞98%
Int 3N/A1353553-07-7＞98%
Int 44-(4-Methylpiperazino)aniline16153-81-4＞98%
Int 52,4-Dichlorothieno[3,2-d]pyrimidine16234-14-3＞98%
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Osimertinib AZD9291, 1421373-65-0 , 99.5%

Osimertinib AZD9291, 1421373-65-0 , 99.5%

TAGRISSO™ (AZD9291) approved by the US FDA for patients with EGFR T790M mutation-positive metastatic non-small cell lung cancer.
EOS Med Chem, finish it in 2015, Nov. EE is 99.5%.
Osimertinib AZD9291
Int 1N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide1421373-65-0＞99.5
Int 2N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro-1,4-benzenediamine1421372-67-9＞98%
Int 3N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine1421372-94-2＞98%
Int 43-(2-Chloro-4-pyrimidinyl)-1-methyl-1H-indole1032452-86-0＞98%
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