EOS Med Chem, Medicinal Chemical is Big

2017年7月13日星期四

Sole supplier: AZD-4635 (CAS NO.1321514-06-0)

World sole supplier: AZD-4635 (CAS NO.1321514-06-0)

HPLC 98

NMR, MS is ok.

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EOS New Drug Impurity

LCZ696Impurity of Sacubitril/Valsartan
曲格列汀Impurity of Trelagliptin succinate
磺达肝癸钠Impurity of Fondaparinux sodium
替格瑞洛（替卡格雷）Impurity of Ticagrelor
依折麦布Impurity of Ezetimibe

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奥贝胆酸Impurity of Obeticholic acid
索氟布韦（索非布韦）Impurity of Sofosbuvir
雷迪帕韦Impurity of Ledipasvir
达卡他韦Impurity of Daclatasvir
恩替卡韦Impurity of Entecavir
替比夫定Impurity of Telbivudine
GS7340(替诺福韦艾拉酚胺)Impurity of TenofovirAlafenamide
泊沙康唑Impurity of Posaconazole
莫西沙星Impurity of Moxifloxacin
头孢洛林酯Impurity of CeftarolineFosamil
磷酸特地唑胺Impurity of Tedizolid phosphate

舒更葡糖钠Impurity of Sugammadex
依匹哌唑Impurity of Brexpiprazole
布瓦西坦Impurity of Brivaracetam

AZD9291Impurity of Mereletinib
阿瑞匹坦Impurity of Aprepitant
福沙匹坦Impurity of Fosaprepitant
阿拉莫林Impurity of Anamorelin

Elagolix & Intermediates, biggest supplier

Elagolix 834153-87-6 & Intermediates, we are China TOP supplier.

Glad to serve you.

Web: www.eosmedchem.com

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1. ethyl (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate cas 832720-84-0 ( Elagolix Intermediates n-1), assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

2. 3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate cas 830346-50-4 (Elagolix Intermediates n-2), assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

3. 3-[(2R)-N-(tert-butoxycarbonyl)amino-2-phenylethyl]-2-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione cas 830346-51-5 (Elagolix Intermediates n-3), assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

4. {(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester cas 830346-49-1 (Elagolix Intermediates n-4), assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

5. (2-fluoro-3-methoxyphenyl)boronic acid cas 352303-67-4, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

6. 1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-bromo-6-methyl-2,4(1H,3H)-pyrimidinedione cas 830346-48-0 (Elagolix Intermediates n-5), assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

7. (R)-N-(tert-butoxycarbonyl)phenylglycinol cas 67341-01-9, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

8. 1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione cas 830346-47-9 (Elagolix Intermediates n-6), assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

9. N-[2-fluoro-6-(trifluoromethyl)benzyl]urea, cas 830346-46-8

10. 4-methyleneoxetan-2-one cas 674-82-8, assay 99% in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

2017年7月12日星期三

GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8

GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8, we are China TOP supplier.

EOS Med Chem produce GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8 in GMP plant, C-GMP standard, now COA, NMR, HPLC, MS is ok.

GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8, EOS Med Chem have 8; 1103738-19-7 Impurity we have 10, all from GMP, FDA plant.

Now GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8 DMF document is preparing.

Until 2016, Aug, GMP Niraparib 1038915-60-4 key Intermediates, 1171197-20-8 more than produced 25kg API, 120kg Intermediates

2017 China CPHI: E1M35

EOS Med Chem, Medchem is Big

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Description: Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.

Name: Niraparib HCl
CAS#: 1038915-64-8 (HCl)
Chemical Formula: C19H21ClN4O
Exact Mass: 356.1404
Molecular Weight: 356.854
Elemental Analysis: C, 63.95; H, 5.93; Cl, 9.93; N, 15.70; O, 4.48

Related CAS #: 1038915-60-4 (free base) 1038915-64-8 (HCl) 1038915-73-9 (tosylate) 1613220-15-7 (tosylate hydrate)
Synonym: MK4827; MK 4827; MK4827; Niraparib; Niraparib HCl; Niraparib hydrochloride.
IUPAC/Chemical Name: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride
InChi Key: YXYDNYFWAFBCAN-PFEQFJNWSA-N
InChi Code: InChI=1S/C19H20N4O.ClH/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);1H/t14-;/m1./s1

SMILES Code: O=C(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C12)N.[H]Cl

2017年7月11日星期二