Original: GW-4869 HC 6823-69-4, stock more than 100g

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.

2018 CHINA CPHI, W4E82

EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.

Description: GW-4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM). GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction.

Name: GW-4869 HCl 

CAS#: 6823-69-4 (HCl) 

Chemical Formula: C30H30Cl2N6O2 

Exact Mass: 

Molecular Weight: 577.51 

Elemental Analysis: C, 62.39; H, 5.24; Cl, 12.28; N, 14.55; O, 5.54

Related CAS #: 6823-69-4 (HCl)   475570-61-7 (free base)    

Synonym: GW4869; GW-4869; GW 4869; GW554869A; GW-554869A; GW 554869A; GW69A; GW-69A; GW 69A; GW-4869 HCl

IUPAC/Chemical Name: (2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride

InChi Key: NSFKAZDTKIKLKT-CLEIDKRQSA-N

InChi Code: InChI=1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5+,16-6+;;

SMILES Code: O=C(/C=C/C1=CC=C(C=C1)/C=C/C(NC2=CC=C(C=C2)C3=NCCN3)=O)NC4=CC=C(C=C4)C5=NCCN5.[H]Cl.[H]Cl

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code: 293490

REFERENCES

1: Sang L, Wang X, Zhao X. Mifepristone Inhibits the Migration of Cervical Cancer Cells by Inhibiting Exocrine Secretion. Pharmacology. 2018 Apr 5;101(5-6):322-329. doi: 10.1159/000488356. [Epub ahead of print] PubMed PMID: 29621762.

2: Lee HY, Chen CK, Ho CM, Lee SS, Chang CY, Chen KJ, Jou YS. EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma. Oncotarget. 2018 Jan 11;9(17):13193-13205. doi: 10.18632/oncotarget.24149. eCollection 2018 Mar 2. PubMed PMID: 29568350; PubMed Central PMCID: PMC5862571.

3: Yang L, Niu F, Yao H, Liao K, Chen X, Kook Y, Ma R, Hu G, Buch S. Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration. J Neuroimmune Pharmacol. 2018 Mar 1. doi: 10.1007/s11481-018-9779-4. [Epub ahead of print] PubMed PMID: 29497921.

4: Panigrahi GK, Praharaj PP, Peak TC, Long J, Singh R, Rhim JS, Elmageed ZYA, Deep G. Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells. Sci Rep. 2018 Mar 1;8(1):3853. doi: 10.1038/s41598-018-22068-4. PubMed PMID: 29497081; PubMed Central PMCID: PMC5832762.

5: Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K. Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. Glia. 2018 May;66(5):1034-1052. doi: 10.1002/glia.23299. Epub 2018 Jan 30. PubMed PMID: 29380419.

6: Won JH, Kim SK, Shin IC, Ha HC, Jang JM, Back MJ, Kim DK. Dopamine transporter trafficking is regulated by neutral sphingomyelinase 2/ceramide kinase. Cell Signal. 2018 Apr;44:171-187. doi: 10.1016/j.cellsig.2018.01.006. Epub 2018 Jan 9. PubMed PMID: 29329781.

7: Zhou W, Woodson M, Neupane B, Bai F, Sherman MB, Choi KH, Neelakanta G, Sultana H. Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells. PLoS Pathog. 2018 Jan 4;14(1):e1006764. doi: 10.1371/journal.ppat.1006764. eCollection 2018 Jan. PubMed PMID: 29300779; PubMed Central PMCID: PMC5754134.

8: Menck K, Sönmezer C, Worst TS, Schulz M, Dihazi GH, Streit F, Erdmann G, Kling S, Boutros M, Binder C, Gross JC. Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane. J Extracell Vesicles. 2017 Sep 26;6(1):1378056. doi: 10.1080/20013078.2017.1378056. eCollection 2017. PubMed PMID: 29184623; PubMed Central PMCID: PMC5699186.

9: Zhang YZ, Liu F, Song CG, Cao XL, Zhang YF, Wu HN, Guo CJ, Li YQ, Zheng QJ, Zheng MH, Han H. Exosomes derived from human umbilical vein endothelial cells promote neural stem cell expansion while maintain their stemness in culture. Biochem Biophys Res Commun. 2018 Jan 1;495(1):892-898. doi: 10.1016/j.bbrc.2017.11.092. Epub 2017 Nov 15. PubMed PMID: 29154990.

10: Chen L, Chen R, Kemper S, Brigstock DR. Pathways of production and delivery of hepatocyte exosomes. J Cell Commun Signal. 2018 Mar;12(1):343-357. doi: 10.1007/s12079-017-0421-7. Epub 2017 Oct 23. PubMed PMID: 29063370; PubMed Central PMCID: PMC5842184.

11: Tan LH, Tan AJ, Ng YY, Chua JJ, Chew WS, Muralidharan S, Torta F, Dutta B, Sze SK, Herr DR, Ong WY. Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. Mol Neurobiol. 2017 Oct 17. doi: 10.1007/s12035-017-0784-z. [Epub ahead of print] PubMed PMID: 29043558.

12: Niu Z, Pang RTK, Liu W, Li Q, Cheng R, Yeung WSB. Polymer-based precipitation preserves biological activities of extracellular vesicles from an endometrial cell line. PLoS One. 2017 Oct 12;12(10):e0186534. doi: 10.1371/journal.pone.0186534. eCollection 2017. PubMed PMID: 29023592; PubMed Central PMCID: PMC5638560.

13: Kavanagh EL, Lindsay S, Halasz M, Gubbins LC, Weiner-Gorzel K, Guang MHZ, McGoldrick A, Collins E, Henry M, Blanco-Fernández A, Gorman PO, Fitzpatrick P, Higgins MJ, Dowling P, McCann A. Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells. Oncogenesis. 2017 Oct 9;6(10):e388. doi: 10.1038/oncsis.2017.82. PubMed PMID: 28991260; PubMed Central PMCID: PMC5668881.

14: Tavakoli Dargani Z, Singla R, Johnson T, Kukreja R, Singla DK. Exosomes derived from embryonic stem cells inhibit doxorubicin and inflammation-induced pyroptosis in muscle cells. Can J Physiol Pharmacol. 2018 Mar;96(3):304-307. doi: 10.1139/cjpp-2017-0340. Epub 2017 Sep 19. PubMed PMID: 28926719.

15: Liu T, Chen G, Sun D, Lei M, Li Y, Zhou C, Li X, Xue W, Wang H, Liu C, Xu J. Exosomes containing miR-21 transfer the characteristic of cisplatin resistance by targeting PTEN and PDCD4 in oral squamous cell carcinoma. Acta Biochim Biophys Sin (Shanghai). 2017 Sep 1;49(9):808-816. doi: 10.1093/abbs/gmx078. PubMed PMID: 28910982.

16: Gon Y, Maruoka S, Inoue T, Kuroda K, Yamagishi K, Kozu Y, Shikano S, Soda K, Lötvall J, Hashimoto S. Selective release of miRNAs via extracellular vesicles is associated with house-dust mite allergen-induced airway inflammation. Clin Exp Allergy. 2017 Dec;47(12):1586-1598. doi: 10.1111/cea.13016. PubMed PMID: 28859242.

17: Cheng Q, Li X, Wang Y, Dong M, Zhan FH, Liu J. The ceramide pathway is involved in the survival, apoptosis and exosome functions of human multiple myeloma cells in vitro. Acta Pharmacol Sin. 2018 Apr;39(4):561-568. doi: 10.1038/aps.2017.118. Epub 2017 Aug 31. PubMed PMID: 28858294.

18: Trajkovic K, Jeong H, Krainc D. Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway. J Neurosci. 2017 Sep 13;37(37):9000-9012. doi: 10.1523/JNEUROSCI.0118-17.2017. Epub 2017 Aug 16. PubMed PMID: 28821645; PubMed Central PMCID: PMC5597981.

19: Cao YL, Zhuang T, Xing BH, Li N, Li Q. Exosomal DNMT1 mediates cisplatin resistance in ovarian cancer. Cell Biochem Funct. 2017 Aug;35(6):296-303. doi: 10.1002/cbf.3276. Epub 2017 Aug 8. PubMed PMID: 28791708.

20: Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B. Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. Sci Rep. 2017 Jul 24;7(1):6301. doi: 10.1038/s41598-017-06443-1. PubMed PMID: 28740179; PubMed Central PMCID: PMC5524687.

Original: Endoxifen E-isomer HCl 1197194-61-8, stock more than 100g

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.

2018 CHINA CPHI, W4E82

EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.

Description: Endoxifen E-isomer is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

Name: Endoxifen E-isomer HCl 

CAS#: 1197194-61-8 (HCl) 

Chemical Formula: C25H28ClNO2 

Exact Mass: 

Molecular Weight: 409.954 

Elemental Analysis: C, 73.25; H, 6.88; Cl, 8.65; N, 3.42; O, 7.81

Related CAS #: 114828-90-9 (free base)   1197194-61-8 (HCl)    

Synonym: Endoxifen E-isomer HCl;

IUPAC/Chemical Name: 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;hydrochloride

InChi Key: RPFIMPDXTABYCN-QREUMGABSA-N

InChi Code: InChI=1S/C25H27NO2.ClH/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;/h4-16,26-27H,3,17-18H2,1-2H3;1H/b25-24+;

SMILES Code: OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1.[H]Cl

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code: 293490

REFERENCES

1: Ford BM, Franks LN, Radominska-Pandya A, Prather PL. Tamoxifen Isomers and 

Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: 

Potential Scaffold for Drug Development. PLoS One. 2016 Dec 9;11(12):e0167240. 

doi: 10.1371/journal.pone.0167240. eCollection 2016. PubMed PMID: 27936172; 

PubMed Central PMCID: PMC5147891.

2: Elkins P, Coleman D, Burgess J, Gardner M, Hines J, Scott B, Kroenke M, Larson 

J, Lightner M, Turner G, White J, Liu P. Characterization of the 

isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution 

LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9. 

doi: 10.1016/j.jpba.2013.07.010. Epub 2013 Jul 24. PubMed PMID: 24055701; PubMed 

Central PMCID: PMC4057282.

3: Fauq AH, Maharvi GM, Sinha D. A convenient synthesis of 

(Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen). Bioorg Med Chem Lett. 2010 May 

15;20(10):3036-8. doi: 10.1016/j.bmcl.2010.03.117. Epub 2010 Apr 3. PubMed PMID: 

20400308.

Original: STO-609 acetate 1173022-21-3 , stock more than 100g

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.

2018 CHINA CPHI, W4E82

EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.

Description: STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ (Ki = 80 and 15 ng/ml, respectively). STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful toName: STO-609 acetate 

CAS#: 1173022-21-3 (acetate) 

Chemical Formula: C21H14N2O5 

Exact Mass: 

Molecular Weight: 374.352 

Elemental Analysis: C, 67.38; H, 3.77; N, 7.48; O, 21.37

Related CAS #: 52029-86-4 (free base)   1173022-21-3 (acetate)    

Synonym: STO-609 acetate; STO 609; STO609;

IUPAC/Chemical Name: 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, monoacetate

InChi Key: InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)

InChi Code: InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)

SMILES Code: O=C(C1=C2C3=C(C4=NC5=CC=CC=C5N4C(C3=CC=C2)=O)C=C1)O.CC(O)=O

ol for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo as well as in vitro.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code: 293490

REFERENCES

1: York B, Li F, Lin F, Marcelo KL, Mao J, Dean A, Gonzales N, Gooden D, Maity S, Coarfa C, Putluri N, Means AR. Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Sci Rep. 2017 Sep 18;7(1):11793. doi: 10.1038/s41598-017-12139-3. PubMed PMID: 28924233; PubMed Central PMCID: PMC5603587.

2: Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP. Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2. Biochem Biophys Res Commun. 2016 Jul 22;476(2):102-7. doi: 10.1016/j.bbrc.2016.05.045. Epub 2016 May 11. PubMed PMID: 27178209.

3: Ma Z, Wen D, Wang X, Yang L, Liu T, Liu J, Zhu J, Fang X. Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase. Am J Transl Res. 2016 Feb 15;8(2):1164-71. eCollection 2016. PubMed PMID: 27158402; PubMed Central PMCID: PMC4846959.

4: Fujiwara Y, Hiraoka Y, Fujimoto T, Kanayama N, Magari M, Tokumitsu H. Analysis of Distinct Roles of CaMKK Isoforms Using STO-609-Resistant Mutants in Living Cells. Biochemistry. 2015 Jun 30;54(25):3969-77. doi: 10.1021/acs.biochem.5b00149. Epub 2015 Jun 18. PubMed PMID: 26050738.

5: Kukimoto-Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S. Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9. doi: 10.1074/jbc.M111.251710. Epub 2011 Apr 19. PubMed PMID: 21504895; PubMed Central PMCID: PMC3121401.

6: Monteiro P, Gilot D, Langouet S, Fardel O. Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). Drug Metab Dispos. 2008 Dec;36(12):2556-63. doi: 10.1124/dmd.108.023333. Epub 2008 Aug 28. PubMed PMID: 18755850.

7: Tokumitsu H, Inuzuka H, Ishikawa Y, Kobayashi R. A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609. J Biol Chem. 2003 Mar 28;278(13):10908-13. Epub 2003 Jan 22. PubMed PMID: 12540834.

8: Tokumitsu H, Inuzuka H, Ishikawa Y, Ikeda M, Saji I, Kobayashi R. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. Epub 2002 Feb 26. Erratum in: J Biol Chem. 2003 Feb 7;278(6):4368. PubMed PMID: 11867640.

Original:YM-58483 223499-30-7 , stock more than 100g

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.

2018 CHINA CPHI, W4E82

EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.

Description: YM-58483, also known as BTP 2, is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM).

Name: YM-58483 

CAS#: 223499-30-7 

Chemical Formula: C15H9F6N5OS 

Exact Mass: 421.0432 

Molecular Weight: 421.3214 

Elemental Analysis: C, 42.76; H, 2.15; F, 27.06; N, 16.62; O, 3.80; S, 7.61

Synonym: YM-58483; YM 58483; YM58483; BTP 2; BTP-2; BTP2.

IUPAC/Chemical Name: N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

InChi Key: XPRZIORDEVHURQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)

SMILES Code: O=C(C1=C(C)N=NS1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code: 293490

REFERENCES

1: Miyoshi M, Liu S, Morizane A, Takemasa E, Suzuki Y, Kiyoi T, Maeyama K, Mogi M. Efficacy of constant long-term delivery of YM-58483 for the treatment of rheumatoid arthritis. Eur J Pharmacol. 2018 Apr 5;824:89-98. doi: 10.1016/j.ejphar.2018.02.006. Epub 2018 Feb 8. PubMed PMID: 29428471.

2: Domenichini F, Terrié E, Arnault P, Harnois T, Magaud C, Bois P, Constantin B, Coronas V. Store-Operated Calcium Entries Control Neural Stem Cell Self-Renewal in the Adult Brain Subventricular Zone. Stem Cells. 2018 Jan 23. doi: 10.1002/stem.2786. [Epub ahead of print] PubMed PMID: 29359518.

3: Wei D, Mei Y, Xia J, Hu H. Orai1 and Orai3 Mediate Store-Operated Calcium Entry Contributing to Neuronal Excitability in Dorsal Root Ganglion Neurons. Front Cell Neurosci. 2017 Dec 19;11:400. doi: 10.3389/fncel.2017.00400. eCollection 2017. PubMed PMID: 29311831; PubMed Central PMCID: PMC5742109.

4: González-Sánchez P, Del Arco A, Esteban JA, Satrústegui J. Store-Operated Calcium Entry Is Required for mGluR-Dependent Long Term Depression in Cortical Neurons. Front Cell Neurosci. 2017 Dec 14;11:363. doi: 10.3389/fncel.2017.00363. eCollection 2017. PubMed PMID: 29311823; PubMed Central PMCID: PMC5735122.

5: Salker MS, Singh Y, Durairaj RRP, Yan J, Alauddin M, Zeng N, Steel JH, Zhang S, Nautiyal J, Webster Z, Brucker SY, Wallwiener D, Anne Croy B, Brosens JJ, Lang F. LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca(2+) entry. J Mol Med (Berl). 2018 Feb;96(2):173-182. doi: 10.1007/s00109-017-1610-9. Epub 2017 Dec 11. PubMed PMID: 29230527; PubMed Central PMCID: PMC5778154.

6: Liu S, Hasegawa H, Takemasa E, Suzuki Y, Oka K, Kiyoi T, Takeda H, Ogasawara T, Sawasaki T, Yasukawa M, Maeyama K. Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models. J Immunol. 2017 Sep 1;199(5):1584-1595. doi: 10.4049/jimmunol.1700192. Epub 2017 Jul 17. PubMed PMID: 28716825.

7: Dart AE, Worth DC, Muir G, Chandra A, Morris JD, McKee C, Verrill C, Bryant RJ, Gordon-Weeks PR. The drebrin/EB3 pathway drives invasive activity in prostate cancer. Oncogene. 2017 Jul 20;36(29):4111-4123. doi: 10.1038/onc.2017.45. Epub 2017 Mar 20. PubMed PMID: 28319065; PubMed Central PMCID: PMC5537610.

8: Zhang W, Qi Z, Wang Y. BTP2, a Store-Operated Calcium Channel Inhibitor, Attenuates Lung Ischemia-Reperfusion Injury in Rats. Inflammation. 2017 Jun;40(3):778-787. doi: 10.1007/s10753-017-0522-8. PubMed PMID: 28168659.

9: Souza Bomfim GH, Mendez-Lopez I, Arranz-Tagarro JA, Ferraz Carbonel AA, Roman-Campos D, Padín JF, Garcia AG, Jurkiewicz A, Jurkiewicz NH. Functional Upregulation of STIM-1/Orai-1-Mediated Store-Operated Ca2+ Contributing to the Hypertension Development Elicited by Chronic EtOH Consumption. Curr Vasc Pharmacol. 2017;15(3):265-281. doi: 10.2174/1570161115666170201122750. PubMed PMID: 28155613.

10: Wang J, Hogan JO, Kim D. Voltage- and receptor-mediated activation of a non-selective cation channel in rat carotid body glomus cells. Respir Physiol Neurobiol. 2017 Mar;237:13-21. doi: 10.1016/j.resp.2016.12.005. Epub 2016 Dec 21. PubMed PMID: 28013061; PubMed Central PMCID: PMC5272830.

11: Wu YL, Xie J, An SW, Oliver N, Barrezueta NX, Lin MH, Birnbaumer L, Huang CL. Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho. Kidney Int. 2017 Apr;91(4):830-841. doi: 10.1016/j.kint.2016.09.039. Epub 2016 Dec 12. PubMed PMID: 27979597; PubMed Central PMCID: PMC5357448.

12: Chan CM, Huang DY, Huang YP, Hsu SH, Kang LY, Shen CM, Lin WW. Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction. J Cell Mol Med. 2016 Sep;20(9):1749-60. doi: 10.1111/jcmm.12893. Epub 2016 Jun 16. PubMed PMID: 27307396; PubMed Central PMCID: PMC4988286.

13: Gao X, Xia J, Munoz FM, Manners MT, Pan R, Meucci O, Dai Y, Hu H. STIMs and Orai1 regulate cytokine production in spinal astrocytes. J Neuroinflammation. 2016 May 31;13(1):126. doi: 10.1186/s12974-016-0594-7. PubMed PMID: 27245842; PubMed Central PMCID: PMC4886427.

14: Sabourin J, Bartoli F, Antigny F, Gomez AM, Benitah JP. Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES. J Biol Chem. 2016 Jun 17;291(25):13394-409. doi: 10.1074/jbc.M115.693911. Epub 2016 Apr 22. PubMed PMID: 27129253; PubMed Central PMCID: PMC4933247.

15: Nguyen TM, Duittoz A, Praud C, Combarnous Y, Blesbois E. Calcium channels in chicken sperm regulate motility and the acrosome reaction. FEBS J. 2016 May;283(10):1902-20. doi: 10.1111/febs.13710. Epub 2016 Apr 13. PubMed PMID: 26990886.

16: Munoz F, Hu H. The Role of Store-operated Calcium Channels in Pain. Adv Pharmacol. 2016;75:139-51. doi: 10.1016/bs.apha.2015.12.005. Epub 2016 Jan 27. Review. PubMed PMID: 26920011.

17: Zuccolo E, Bottino C, Diofano F, Poletto V, Codazzi AC, Mannarino S, Campanelli R, Fois G, Marseglia GL, Guerra G, Montagna D, Laforenza U, Rosti V, Massa M, Moccia F. Constitutive Store-Operated Ca(2+) Entry Leads to Enhanced Nitric Oxide Production and Proliferation in Infantile Hemangioma-Derived Endothelial Colony-Forming Cells. Stem Cells Dev. 2016 Feb 15;25(4):301-19. doi: 10.1089/scd.2015.0240. Epub 2016 Jan 26. PubMed PMID: 26654173.

18: Zhong W, Chebolu S, Darmani NA. Thapsigargin-induced activation of Ca(2+)-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew. Neuropharmacology. 2016 Apr;103:195-210. doi: 10.1016/j.neuropharm.2015.11.023. Epub 2015 Nov 26. PubMed PMID: 26631534.

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20: Gao XH, Gao R, Tian YZ, McGonigle P, Barrett JE, Dai Y, Hu H. A store-operated calcium channel inhibitor attenuates collagen-induced arthritis. Br J Pharmacol. 2015 Jun;172(12):2991-3002. doi: 10.1111/bph.13104. Epub 2015 Mar 27. PubMed PMID: 25651822; PubMed Central PMCID: PMC4459018.

Original:ISCK03 945526-43-2 , stock more than 100g

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.

2018 CHINA CPHI, W4E82

EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.

Description: ISCK03 is a potent c-kit inhibitor. ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents.

Name: ISCK03 

CAS#: 945526-43-2 

Chemical Formula: C19H21N3O2S 

Exact Mass: 355.1354 

Molecular Weight: 355.456 

Elemental Analysis: C, 64.20; H, 5.96; N, 11.82; O, 9.00; S, 9.02

Synonym: ISCK03, ISCK-03, ISCK 03.

IUPAC/Chemical Name: [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide

InChi Key: YKRCYYGZFGRSAX-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21N3O2S/c1-19(2,3)15-4-6-17(7-5-15)22(25(23)24)18-10-8-16(9-11-18)21-13-12-20-14-21/h4-14,25H,1-3H3

SMILES Code: O=S(N(C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(N3C=CN=C3)C=C2)=O

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code: 293490

REFERENCES

1: Na YJ, Baek HS, Ahn SM, Shin HJ, Chang IS, Hwang JS. 

[4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits 

SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin 

production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep 

1;74(5):780-6. Epub 2007 Jun 14. PubMed PMID: 17658483.

2: Kamlah F, Hänze J, Arenz A, Seay U, Hasan D, Juricko J, Bischoff B, Gottschald 

OR, Fournier C, Taucher-Scholz G, Scholz M, Seeger W, Engenhart-Cabillic R, Rose 

F. Comparison of the effects of carbon ion and photon irradiation on the 

angiogenic response in human lung adenocarcinoma cells. Int J Radiat Oncol Biol 

Phys. 2011 Aug 1;80(5):1541-9. doi: 10.1016/j.ijrobp.2011.03.033. Epub 2011 May 

27. PubMed PMID: 21621345.

3: Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, Yamazaki T. Long 

noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation 

of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7. 

PubMed PMID: 25928165; PubMed Central PMCID: PMC4423487.

Original:TLR2-IN-C29 363600-92-4 , stock more than 100g

EOS med chem is the only manufacturer that provides excellent quality chemistry products and services at affordable rates. The experts working here are highly trained to handle these chemicals used in the creation of medicines used for treating various life-threatening diseases. We are into the manufacturing of chemical products after doing a deep research for the same.

EOS team of experts holds the work experience of more than ten years, and therefore we can assure you about the quality and superiority of the products and services we offer to all our valued clients around the globe. At present, this organization is listed among the most leading pharmaceutical suppliers around the world. We always supply products keeping the affordability in mind.

2018 CHINA CPHI, W4E82

EOS Med Chem, Medchem is Big
執大象，天下往，往而無害，安平泰
WEB: www.eosmedchem.com
EMAIL: info@eosmedchem.com; eosmedchem@gmail.com; eosmedchem@qq.com  
TEL: 0086-531-69905422
GMP PLANT: No. 37, Yulong Road, Qufu City, Shandong Province.

Description: TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.

Name: TLR2-IN-C29 

CAS#: 363600-92-4 

Chemical Formula: C16H15NO4 

Exact Mass: 285.1001 

Molecular Weight: 285.29 

Elemental Analysis: C, 67.36; H, 5.30; N, 4.91; O, 22.43

Synonym: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29;

IUPAC/Chemical Name: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid

InChi Key: WTGMGRFVBFDHGQ-RQZCQDPDSA-N

InChi Code: InChI=1S/C16H15NO4/c1-10-12(16(19)20)6-4-7-13(10)17-9-11-5-3-8-14(21-2)15(11)18/h3-9,18H,1-2H3,(H,19,20)/b17-9+

SMILES Code: O=C(O)C1=CC=CC(/N=C/C2=CC=CC(OC)=C2O)=C1C

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code: 293490

REFERENCES

1: Mistry P, Laird MH, Schwarz RS, Greene S, Dyson T, Snyder GA, Xiao TS, Chauhan J, Fletcher S, Toshchakov VY, MacKerell AD Jr, Vogel SN. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. doi: 10.1073/pnas.1422576112. Epub 2015 Apr 13. PubMed PMID: 25870276; PubMed Central PMCID: PMC4418912.